ESRRG ( estrogen - related receptor gamma )

ERRgamma has 4 coding and 1 (presumed) non-coding transcript variants. ERRgamma transcript variant 1 (NCBI, NM_001438) is the longest isoform, while ERRgamma transcript variant 2 (NM_206594) utilizes an alternate 5' UTR and lacks the first 23 amino acids of the coding sequence of variant 1 (Heard et al., 2000). In 2006, a third splice variant (ERRgamma3, NM_206595) was identified (Kojo et al., 2006). This isoform has 3 novel amino-terminal exons and lacks Exon F, which contains the second zinc-finger binding motif within the DNA binding domain of the receptor. Consequently ERRgamma3 cannot stimulate transcription from an estrogen response element (ERE)driven reporter construct, although it can modulate the activity of other nuclear receptors, such as estrogen receptors alpha and beta (ERalpha, ERbeta), thyroid hormone receptor (TR), and glucocorticoid receptor (GR) (Kojo et al., 2006). ERRgamma4 (NM_001134285), similar to variant 2, uses an alternate 5' UTR and also encodes a shorter protein isoform than variant 1. ERRgamma5 (NR_024099) is transcribed but presumed to be non-coding.